The fidelity of mitotic chromosome segregation relies on kinetochores detecting sister chromatid bi-orientation to control error correction (EC) and the spindle assembly checkpoint (SAC). The kinetochore-microtubule attachment state needs to be decoded, the signal processed, and transduced, resulting in either stabilization or destabilization of the attachment. Although many crucial players of this process have been identified, the molecular mechanisms underlying signal integration remain an open question. Focusing on the model system Saccharomyces cerevisiae, we explore the interdependent contributions of the conserved protein kinases Mps1 and Ipl1Aurora B, crucial regulators of mitotic chromosome segregation. We discuss how bi-orientation reorganizes the kinetochore attachment site and we present a perspective on how these structural changes can alter kinase localization and activity.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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