Primary Literature
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- Afonin D, et al. (2025) H2A.Z and H3:K56Q Affect Transcription Through Chromatin and Yeast FACT-Dependent Nucleosome Unfolding. Int J Mol Sci 26(22) PMID: 41303375
- Barman P, et al. (2025) TAP-MS analysis of FACT interactions and regulation by a ubiquitin ligase, San1. Biochim Biophys Acta Gene Regul Mech 1868(1):195077 PMID: 39855624
- Burgos-Bravo F, et al. (2025) FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate. Mol Cell 85(11):2097-2109.e8 PMID: 40412388
- Warner JL, et al. (2025) The histone chaperone Spt6 controls chromatin structure through its conserved N-terminal domain. Mol Cell 85(18):3407-3424.e8 PMID: 40972526
- Byrd SE, et al. (2024) Assessing contributions of DNA sequences at the 3' end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy. BMC Res Notes 17(1):219 PMID: 39103906
- Geisberg JV, et al. (2024) Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate. Proc Natl Acad Sci U S A 121(21):e2405827121 PMID: 38748572
- Li N, et al. (2024) Parental histone transfer caught at the replication fork. Nature 627(8005):890-897 PMID: 38448592
- Yu J, et al. (2024) A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance. Cell 187(18):5010-5028.e24 PMID: 39094570
- Gaur NK, et al. (2023) Evolutionary conservation of protein dynamics: insights from all-atom molecular dynamics simulations of 'peptidase' domain of Spt16. J Biomol Struct Dyn 41(4):1445-1457 PMID: 34971347
- Shan Z, et al. (2023) The patterns and participants of parental histone recycling during DNA replication in Saccharomyces cerevisiae. Sci China Life Sci 66(7):1600-1614 PMID: 36914923
- Wang X, et al. (2023) The N-terminus of Spt16 anchors FACT to MCM2-7 for parental histone recycling. Nucleic Acids Res 51(21):11549-11567 PMID: 37850662
- Malinina DK, et al. (2022) Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT. Cells 11(19) PMID: 36230893
- Reusswig KU, et al. (2022) Unscheduled DNA replication in G1 causes genome instability and damage signatures indicative of replication collisions. Nat Commun 13(1):7014 PMID: 36400763
- Sivkina AL, et al. (2022) Electron microscopy analysis of ATP-independent nucleosome unfolding by FACT. Commun Biol 5(1):2 PMID: 35013515
- Jeronimo C, et al. (2021) FACT is recruited to the +1 nucleosome of transcribed genes and spreads in a Chd1-dependent manner. Mol Cell 81(17):3542-3559.e11 PMID: 34380014
- Jo H, et al. (2021) A compendium of chromatin contact maps reflecting regulation by chromatin remodelers in budding yeast. Nat Commun 12(1):6380 PMID: 34737268
- Shukla A, et al. (2021) Transcription-dependent enrichment of the yeast FACT complex influences nucleosome dynamics on the RNA polymerase III-transcribed genes. RNA 27(3):273-290 PMID: 33277439
- Abd Wahab S and Remus D (2020) Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53. Elife 9 PMID: 32701054
- Kozlova AL, et al. (2018) [HMGB Proteins as DNA Chaperones That Modulate Chromatin Activity]. Mol Biol (Mosk) 52(5):737-749 PMID: 30363049
- Nyamugenda E, et al. (2018) Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast. Epigenetics 13(1):1-7 PMID: 29271283
- Pathak R, et al. (2018) Acetylation-Dependent Recruitment of the FACT Complex and Its Role in Regulating Pol II Occupancy Genome-Wide in Saccharomyces cerevisiae. Genetics 209(3):743-756 PMID: 29695490
- Vinayachandran V, et al. (2018) Widespread and precise reprogramming of yeast protein-genome interactions in response to heat shock. Genome Res 28(3):357-366 PMID: 29444801
- Valieva ME, et al. (2017) Stabilization of Nucleosomes by Histone Tails and by FACT Revealed by spFRET Microscopy. Cancers (Basel) 9(1) PMID: 28067802
- Marcianò G and Huang DT (2016) Structure of the human histone chaperone FACT Spt16 N-terminal domain. Acta Crystallogr F Struct Biol Commun 72(Pt 2):121-8 PMID: 26841762
- Valero ML, et al. (2016) Tandem affinity purification of histones, coupled to mass spectrometry, identifies associated proteins and new sites of post-translational modification in Saccharomyces cerevisiae. J Proteomics 136:183-92 PMID: 26778144
- Deyter GM and Biggins S (2014) The FACT complex interacts with the E3 ubiquitin ligase Psh1 to prevent ectopic localization of CENP-A. Genes Dev 28(16):1815-26 PMID: 25128498
- Tessarz P, et al. (2014) Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. Nature 505(7484):564-8 PMID: 24352239
- Voth WP, et al. (2014) A role for FACT in repopulation of nucleosomes at inducible genes. PLoS One 9(1):e84092 PMID: 24392107
- Busnelli S, et al. (2013) Snf1/AMPK promotes SBF and MBF-dependent transcription in budding yeast. Biochim Biophys Acta 1833(12):3254-3264 PMID: 24084603
- McCullough L, et al. (2013) The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae. Genetics 195(1):101-13 PMID: 23833181
- Formosa T (2012) The role of FACT in making and breaking nucleosomes. Biochim Biophys Acta 1819(3-4):247-55 PMID: 21807128
- Mazzio EA and Soliman KF (2012) Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics 7(2):119-30 PMID: 22395460
- Avvakumov N, et al. (2011) Histone chaperones: modulators of chromatin marks. Mol Cell 41(5):502-14 PMID: 21362547
- Mahapatra S, et al. (2011) Yeast H2A.Z, FACT complex and RSC regulate transcription of tRNA gene through differential dynamics of flanking nucleosomes. Nucleic Acids Res 39(10):4023-34 PMID: 21266479
- Myers CN, et al. (2011) Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3. PLoS One 6(6):e20847 PMID: 21673966
- Nair DM, et al. (2011) Genetic interactions between POB3 and the acetylation of newly synthesized histones. Curr Genet 57(4):271-86 PMID: 21656278
- Winkler DD and Luger K (2011) The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. J Biol Chem 286(21):18369-74 PMID: 21454601
- Mayer A, et al. (2010) Uniform transitions of the general RNA polymerase II transcription complex. Nat Struct Mol Biol 17(10):1272-8 PMID: 20818391
- Morillo-Huesca M, et al. (2010) FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. PLoS Genet 6(5):e1000964 PMID: 20502685
- Stillman DJ (2010) Nhp6: a small but powerful effector of chromatin structure in Saccharomyces cerevisiae. Biochim Biophys Acta 1799(1-2):175-80 PMID: 20123079
- Jimeno-González S, et al. (2006) A gene-specific requirement for FACT during transcription is related to the chromatin organization of the transcribed region. Mol Cell Biol 26(23):8710-21 PMID: 17000768
- Pérez-González A, et al. (2006) hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. J Mol Biol 362(5):887-900 PMID: 16950395
- Biswas D, et al. (2005) The yeast FACT complex has a role in transcriptional initiation. Mol Cell Biol 25(14):5812-22 PMID: 15987999
- Rhoades AR, et al. (2004) Structural features of nucleosomes reorganized by yeast FACT and its HMG box component, Nhp6. Mol Cell Biol 24(9):3907-17 PMID: 15082784
- Schwabish MA and Struhl K (2004) Evidence for eviction and rapid deposition of histones upon transcriptional elongation by RNA polymerase II. Mol Cell Biol 24(23):10111-7 PMID: 15542822
- Tan BC and Lee SC (2004) Nek9, a novel FACT-associated protein, modulates interphase progression. J Biol Chem 279(10):9321-30 PMID: 14660563
- Mason PB and Struhl K (2003) The FACT complex travels with elongating RNA polymerase II and is important for the fidelity of transcriptional initiation in vivo. Mol Cell Biol 23(22):8323-33 PMID: 14585989
- Ruone S, et al. (2003) Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes. J Biol Chem 278(46):45288-95 PMID: 12952948
- Formosa T, et al. (2002) Defects in SPT16 or POB3 (yFACT) in Saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: polymerase passage may degrade chromatin structure. Genetics 162(4):1557-71 PMID: 12524332
- Brewster NK, et al. (2001) A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription. Mol Cell Biol 21(10):3491-502 PMID: 11313475