Primary Literature
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- Beckwitt EC, et al. (2026) Dpb11 facilitates the colocalization of Mec1-Ddc2 with its activators on gapped DNA. Cell Rep 45(7):117660 PMID: 42441399
- Ma M, et al. (2020) Activation of ATR-related protein kinase upon DNA damage recognition. Curr Genet 66(2):327-333 PMID: 31624858
- Deshpande I, et al. (2017) Structural Basis of Mec1-Ddc2-RPA Assembly and Activation on Single-Stranded DNA at Sites of Damage. Mol Cell 68(2):431-445.e5 PMID: 29033322
- Wang X, et al. (2017) 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP. Science 358(6367):1206-1209 PMID: 29191911
- Feng W (2016) Mec1/ATR, the Program Manager of Nucleic Acids Inc. Genes (Basel) 8(1) PMID: 28036033
- Poli J, et al. (2016) Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress. Genes Dev 30(3):337-54 PMID: 26798134
- Sawicka M, et al. (2016) The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization. J Biol Chem 291(26):13436-47 PMID: 27129217
- Hustedt N, et al. (2015) Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling. Mol Cell 57(2):273-89 PMID: 25533186
- Sánchez A, et al. (2015) Genetic Interaction Landscape Reveals Critical Requirements for Schizosaccharomyces pombe Brc1 in DNA Damage Response Mutants. G3 (Bethesda) 5(5):953-62 PMID: 25795664
- DaSilva LF, et al. (2013) The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function. G3 (Bethesda) 3(10):1661-74 PMID: 23934994
- Navadgi-Patil VM and Burgers PM (2009) The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms. Mol Cell 36(5):743-53 PMID: 20005839
- Mordes DA and Cortez D (2008) Activation of ATR and related PIKKs. Cell Cycle 7(18):2809-12 PMID: 18769153
- Mordes DA, et al. (2008) Dpb11 activates the Mec1-Ddc2 complex. Proc Natl Acad Sci U S A 105(48):18730-4 PMID: 19028869
- Navadgi-Patil VM and Burgers PM (2008) Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase. J Biol Chem 283(51):35853-9 PMID: 18922789
- Kanoh Y, et al. (2006) Different requirements for the association of ATR-ATRIP and 9-1-1 to the stalled replication forks. Gene 377:88-95 PMID: 16753272
- Zou L and Elledge SJ (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300(5625):1542-8 PMID: 12791985
- Desany BA, et al. (1998) Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway. Genes Dev 12(18):2956-70 PMID: 9744871