SLM4 / YBR077C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

SLM4/YBR077C is a non-essential gene in reference strain S288C; null mutants are viable but display decreased autophagy and reticulophagy, decreased nutrient uptake, decreased utilization of carbon and nitrogen sources, decreased fermentative growth rate, and auxotrophy for certain nutrients. Stress resistance phenotypes are complex and context-dependent: null mutants show decreased acquired and innate thermotolerance (though innate thermotolerance is increased in some conditions), increased heat sensitivity, increased cold sensitivity, decreased hydrostatic pressure resistance, decreased oxidative stress resistance, decreased starvation resistance, and variable resistance to chemicals (both increased and decreased depending on the compound), though killer toxin resistance is increased and overall stress resistance is increased in some conditions. Null mutants display abnormal and increased accumulation of certain chemical compounds, increased chitin deposition, decreased protein/peptide modification, and abnormal vacuolar morphology. Lifespan effects include abnormal replicative lifespan, increased chronological lifespan, and increased sporulation efficiency. Additional phenotypes include decreased competitive fitness, decreased resistance to enzymatic treatment, decreased transposable element transposition, and decreased metal resistance. Overexpression of SLM4 results in increased colony sectoring.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources