ZNF1 / YFL052W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene in reference strain S288C; null mutant has decreased respiratory growth on nonfermentable carbon sources with abnormal mitochondrial morphology and defective Oxa1p localization; decreased ATP levels and altered metabolite accumulation including increased ethanol, glucose, and glycerol; decreased resistance to acid pH, alkaline pH, osmotic stress, heat, Calcofluor White, ethanol, isobutanol, acetic acid, formic acid, and benzo[a]pyrene but increased resistance to CG-1521; overexpression increases resistance to ethanol, organic acids, and other stress compounds while decreasing glycerol and ethanol accumulation; null mutant shows altered mRNA expression of stress response and metabolic genes; decreased utilization of fatty acids and urea, decreased starvation resistance; overexpression increases exponential growth while null mutant decreases it; increased competitive fitness in minimal medium; is haploinsufficient under turbidostat growth conditions; in large-scale studies, displays defective vacuolar fragmentation

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources