LOC1 / YFR001W Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

LOC1/YFR001W is a non-essential gene in reference strain S288C; null mutants are viable but grow slowly with decreased fermentative growth rate, decreased vegetative growth, increased G1 phase duration, haploinsufficiency, and decreased competitive fitness. Null mutants exhibit abnormal, decreased, and increased accumulation of different chemical compounds, decreased and increased RNA accumulation, abnormal RNA localization, decreased protein/peptide accumulation, abnormal budding pattern, abnormal cell shape, decreased cell size, abnormal vacuolar morphology, decreased endocytosis, and decreased peroxisomal transport. Stress resistance phenotypes are highly context-dependent: null mutants show increased heat sensitivity, decreased desiccation resistance, decreased freeze-thaw resistance, decreased metal resistance, variable overall stress resistance (both increased and decreased depending on conditions), and variable resistance to chemicals (both increased and decreased depending on the compound), while resistance to enzymatic treatment and toxin resistance are increased. Null mutants display absent or decreased utilization of nitrogen sources, decreased mitotic recombination, decreased transposable element transposition, increased chronological lifespan, and variable replicative lifespan (both increased and decreased depending on conditions). Overexpression of LOC1 results in increased filamentous growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources