ATG18 / YFR021W Homology
- Standard Name
- ATG18 1
- Systematic Name
- YFR021W
- SGD ID
- SGD:S000001917
- Aliases
- CVT18 15 , AUT10 2 , SVP1 4 , NMR1 14
- Feature Type
- ORF , Verified
- Description
- Phosphoinositide binding protein; binds PI(3,5)P2 with high affinity; required for vacuolar membrane scission; activates Atg2p lipid transfer activity; required for the CVT pathway, autophagic vesicle and autophagosome formation; PROPPIN family member with WD-40 repeats and an AIM motif; PI(3,5)P2 induces higher order helical assemblies; relocalizes from the vacuole to cytoplasm upon replication stress; functional homolog of human WDR45, mutations of which cause BPAN, a neurodegenerative disease 2 3 4 5 6 7 8 9 10 11 12 13
- Name Description
- AuTophaGy related 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
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| Alias ID | External ID | Source |
|---|
Resources
Homologs
AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | PomBase | YGOB | YOGY | CGD Synteny Browser
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | LibrarYeast | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi