NBP2 / YDR162C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

NBP2/YDR162C is a non-essential gene in reference strain S288C; null mutants are viable but grow slowly and display haploproficiency in some conditions, decreased respiratory growth rate, decreased utilization of carbon and nitrogen sources, auxotrophy for certain nutrients, and decreased competitive fitness. Null mutants exhibit abnormal and increased accumulation of certain chemical compounds, increased chitin deposition, increased protein/peptide modification, abnormal colony appearance, and decreased sporulation. Stress resistance phenotypes are context-dependent: null mutants show increased heat sensitivity, decreased hydrostatic pressure resistance, decreased hyperosmotic stress resistance, decreased oxidative stress resistance, decreased metal resistance, decreased resistance to enzymatic treatment, decreased toxin resistance, and variable resistance to chemicals (both increased and decreased depending on the compound), though killer toxin resistance is increased. Overexpression of NBP2 results in increased filamentous growth, increased invasive growth, and decreased vegetative growth rate. Conditional alleles display decreased toxin resistance.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources