RIM21 / YNL294C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

RIM21/YNL294C is a non-essential gene in reference strain S288C; null mutants are viable but grow slowly and display decreased competitive fitness in most conditions, though increased in some. Null mutants exhibit abnormal vacuolar morphology, abnormal colony appearance, abnormal liquid culture appearance, decreased endocytosis, and absent respiratory growth. Stress resistance phenotypes are highly context-dependent: null mutants show decreased alkaline pH resistance, decreased ionic stress resistance, decreased hyperosmotic stress resistance, decreased desiccation resistance, increased heat sensitivity, decreased oxidative stress resistance, decreased resistance to enzymatic treatment, decreased toxin resistance, variable overall stress resistance (both increased and decreased depending on conditions), variable metal resistance (both increased and decreased depending on the metal), and variable resistance to chemicals (both increased and decreased depending on the compound). Null mutants display increased chronological lifespan and decreased prion formation. Overexpression of RIM21 results in decreased vegetative growth.

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources