GDH1 / YOR375C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

Non-essential gene in reference strain S288C; null mutant accumulates 2-Non-essential gene in reference strain S288C; null mutant has disrupted amino acid metabolism with increased glutamate and 2-oxoglutarate accumulation when grown on glucose, decreased asparagine levels; shows severe respiratory defects with absent growth on glycerol and other non-fermentable carbon sources, altered redox state, and variable effects on alcohol production during fermentation; has increased chronological lifespan despite decreased competitive fitness and growth defects; displays mixed stress responses with decreased resistance to ethanol and some drugs but increased resistance to lithium and zinc deficiency; shows signs of cellular stress including increased glutathione excretion, enhanced Rad52 foci formation, and altered Gap1p trafficking; abnormal colony morphology in Sigma1278b and small vacuolar defects; is haploinsufficient under turbidostat conditions; the null mutant of paralog gdh3 is viable; the gdh1 gdh3 double mutant is inviable or displays a growth defect

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources