Pathway: superpathway of chorismate metabolism
Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.
- Pathway Name
- superpathway of chorismate metabolism
- Pathway ID
- ALL-CHORISMATE-PWY-1
- SGD ID
- SGD:S000249665
- Genes
- ABZ1 | ABZ2 | ADE3 | ARO1 | ARO2 | ARO3 | ARO4 | ARO7 | ARO8 | ARO9 | CDC21 | DFR1 | FOL1 | FOL2 | FOL3 | GCV1 | GCV2 | GCV3 | HIS5 | LPD1 | MET12 | MET13 | MIS1 | MTD1 | PHA2 | SHM1 | SHM2 | TRP1 | TRP2 | TRP3 | TRP4 | TRP5 | TYR1
- Chemical Compounds
- (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate(2-) | (1s,4s)-prephenate(2-) | (7,8-dihydropterin-6-yl)methyl diphosphate | 1-(2-carboxylatophenylamino)-1-deoxy-D-ribulose 5-phosphate(3-) | 1H-indole | 2-amino-6-(hydroxymethyl)-7,8-dihydropteridin-4-one | 2-oxoglutarate(2-) | 3-(4-hydroxyphenyl)pyruvate | 3-dehydroquinate | 3-dehydroshikimate | 3-phosphonatoshikimate(3-) | 4-amino-4-deoxychorismate(1-) | 4-aminobenzoate | 5-O-(1-carboxylatovinyl)-3-phosphonatoshikimate | 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) | 7,8-dihydroneopterin | 7,8-dihydroneopterin 3'-phosphate(2-) | 7,8-dihydroneopterin 3'-triphosphate(4-) | 7,8-dihydropteroate | 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate | ADP(3-) | ATP(4-) | D-erythrose 4-phosphate(2-) | D-glyceraldehyde 3-phosphate(2-) | GTP(4-) | L-alanine zwitterion | L-glutamate(1-) | L-glutamine zwitterion | L-phenylalanine zwitterion | L-serine zwitterion | L-tryptophan zwitterion | L-tyrosine zwitterion | N-(5-phosphonato-beta-D-ribosyl)anthranilate | NAD(1-) | NAD(P)(+) | NAD(P)H | NADH(2-) | NADP(3-) | NADPH(4-) | adenosine 5'-monophosphate(2-) | ammonium | anthranilate | carbon dioxide | chorismate(2-) | dTMP(2-) | dUMP(2-) | dihydrofolate(2-) | diphosphoric acid | formate | glycine zwitterion | glycolaldehyde | hydrogenphosphate | hydron | keto-phenylpyruvate | phosphonatoenolpyruvate | pyruvate | shikimate | water
Pathway Summary
Chorismate is an intermediate in the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan and the vitamins, p-aminobenzoate and p-hydroxybenzoate The series of reactions to chorismate, called the shikimate pathway, are common for all of the aforementioned compounds, at which point the pathway branches One branch proceeds to tryptophan, one to phenylalanine and tyrosine, one to p-aminobenzoate, and one to p-hydroxybenzoate Aromatic amino acid biosynthesis in S. cerevisiae is controlled by a combination of feedback inhibition, activation of enzyme activity, and regulation of enzyme synthesis The carbon flow through the pathways is regulated primarily at the initial step and the branching points by the terminal end-products. The initial step of chorismate biosynthesis can be catalyzed by two isoenzymes, one of which (ARO3) is inhibited by phenylalanine, and the other (ARO4) by tyrosine The first step in the phenylalanine-tyrosine branch is feedback inhibited by tyrosine and activated by tryptophan , and the first step in the tryptophan branch is feedback inhibited by tryptophan. The transcriptional activator GCN4 regulates most of the genes encoding for the aromatic amino acid biosynthetic enzymes.
Genes Involved
Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.
| Gene | Systematic Name | EC Number | Description |
|---|---|---|---|
| ABZ1 | YNR033W | 2.6.1.85 | Para-aminobenzoate (PABA) synthase |
| ABZ2 | YMR289W | 4.1.3.38 | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) |
| ADE3 | YGR204W | 1.5.1.5, 3.5.4.9, 6.3.4.3 | Cytoplasmic trifunctional enzyme |
| ARO1 | YDR127W | 1.1.1.25, 2.5.1.19, 2.7.1.71, 4.2.1.10, 4.2.3.4 | Pentafunctional arom protein |
| ARO2 | YGL148W | 1.5.1.38, 4.2.3.5 | Bifunctional chorismate synthase and flavin reductase |
| ARO3 | YDR035W | 2.5.1.54 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
| ARO4 | YBR249C | 2.5.1.54 | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
| ARO7 | YPR060C | 5.4.99.5 | Chorismate mutase |
| ARO8 | YGL202W | 2.6.1.39, 2.6.1.57 | Aromatic aminotransferase I |
| ARO9 | YHR137W | 2.6.1.57, 2.6.1.7 | Aromatic aminotransferase II |
| CDC21 | YOR074C | 2.1.1.45 | Thymidylate synthase |
| DFR1 | YOR236W | 1.5.1.3 | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
| FOL1 | YNL256W | 2.5.1.15, 2.7.6.3, 4.1.2.25 | Multifunctional enzyme of the folic acid biosynthesis pathway |
| FOL2 | YGR267C | 3.5.4.16 | GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis |
| FOL3 | YMR113W | 6.3.2.12 | Dihydrofolate synthetase, involved in folic acid biosynthesis |
| GCV1 | YDR019C | 2.1.2.10 | T subunit of the mitochondrial glycine decarboxylase complex |
| GCV2 | YMR189W | 1.4.4.2 | P subunit of the mitochondrial glycine decarboxylase complex |
| GCV3 | YAL044C | H subunit of the mitochondrial glycine decarboxylase complex | |
| HIS5 | YIL116W | 2.6.1.9 | Histidinol-phosphate aminotransferase |
| LPD1 | YFL018C | 1.8.1.4 | Dihydrolipoamide dehydrogenase |
| MET12 | YPL023C | 1.5.1.20 | Protein with MTHFR activity in vitro |
| MET13 | YGL125W | 1.5.1.53 | Major isozyme of methylenetetrahydrofolate reductase |
| MIS1 | YBR084W | 1.5.1.5, 3.5.4.9, 6.3.4.3 | Mitochondrial C1-tetrahydrofolate synthase |
| MTD1 | YKR080W | 1.5.1.15 | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase |
| PHA2 | YNL316C | 4.2.1.51 | Prephenate dehydratase |
| SHM1 | YBR263W | 2.1.2.1 | Mitochondrial serine hydroxymethyltransferase |
| SHM2 | YLR058C | 2.1.2.1 | Cytosolic serine hydroxymethyltransferase |
| TRP1 | YDR007W | 5.3.1.24 | Phosphoribosylanthranilate isomerase |
| TRP2 | YER090W | 4.1.3.27 | Anthranilate synthase |
| TRP3 | YKL211C | 4.1.1.48, 4.1.3.27 | Indole-3-glycerol-phosphate synthase |
| TRP4 | YDR354W | 2.4.2.18 | Anthranilate phosphoribosyl transferase |
| TRP5 | YGL026C | 4.2.1.20 | Tryptophan synthase |
| TYR1 | YBR166C | 1.3.1.13 | Prephenate dehydrogenase involved in tyrosine biosynthesis |
Functional Networks
Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.
Shared Annotations
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GO-CAMs
GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.
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References
List of references used specifically to curate the information on this page.
- Braus GH (1991) Aromatic amino acid biosynthesis in the yeast Saccharomyces cerevisiae: a model system for the regulation of a eukaryotic biosynthetic pathway. Microbiol Rev 55(3):349-70 PMID: 1943992
Resources
YeastPathways