AboutBlogDownloadExploreHelpGet Data

Pathway: superpathway of ergosterol biosynthesis I

Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.

Pathway Name
superpathway of ergosterol biosynthesis I
Pathway ID
ERGOSTEROL-SYN-PWY-1
SGD ID
SGD:S000249677
Genes
ERG1 | ERG10 | ERG11 | ERG12 | ERG13 | ERG2 | ERG20 | ERG24 | ERG25 | ERG26 | ERG27 | ERG3 | ERG4 | ERG5 | ERG6 | ERG7 | ERG8 | ERG9 | HMG1 | HMG2 | IDI1 | MVD1
Aliases
superpathway of ergosterol biosynthesis I (fungi)
Chemical Compounds
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) | (R)-5-diphosphonatomevalonate(4-) | (R)-5-phosphonatomevalonate(3-) | (R)-mevalonate | (S)-2,3-epoxysqualene | 14-demethyllanosterol | 2-trans,6-trans-farnesyl diphosphate(3-) | 3-dehydro-4alpha-methylzymosterol | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol | 4alpha-hydroxymethyl-4beta-methylzymosterol | 4alpha-methylzymosterol | 4beta-methylzymosterol-4-carbaldehyde | 4beta-methylzymosterol-4alpha-carboxylate | 9xi-episterol | ADP(3-) | ATP(4-) | NAD(P)(+) | NAD(P)H | NADP(3-) | NADPH(4-) | S-adenosyl-L-homocysteine zwitterion | S-adenosyl-L-methionine zwitterion | acceptor | acetoacetyl-CoA(4-) | acetyl-CoA(4-) | carbon dioxide | coenzyme A(4-) | dioxygen | diphosphoric acid | ergosta-5,7,22,24(28)-tetraen-3beta-ol | ergosta-5,7,24(28)-trien-3beta-ol | ergosterol | fecosterol | formate | geranyl diphosphate(3-) | hydrogen donor | hydrogenphosphate | hydron | isopentenyl diphosphate(3-) | lanosterol | prenyl diphosphate(3-) | presqualene diphosphate(3-) | squalene | water | zymosterol | zymosterone

Pathway Diagram

Diagram of the pathway from YeastPathways. Click "View interactive diagram at YeastPathways" for the zoomable, clickable version.

superpathway of ergosterol biosynthesis I pathway diagram

View interactive diagram at YeastPathways

Pathway Summary

The ergosterol biosynthesis pathway is required for generation of a major constituent of the fungal plasma membrane, ergosterol This pathway is fungal-specific; plasma membranes of other organisms are composed predominantly of other types of sterol. However, the pathway is not universally present in fungi; for example, Pneumocystis carinii plasma membranes lack ergosterol In S. cerevisiae, some steps in the pathway are dispensible while others are essential for viability The ergosterol biosynthesis pathway has been the subject of intensive investigation as a target of antifungal drugs The major target of azole antifungal drugs is lanosterol 14-alpha demethylase, a member of the cytochrome P450 family known as Erg11 protein in many fungal species. Squalene epoxidase (Erg1p in S. cerevisiae) is the specific target of allylamine drugs such as terbinafine Mutations in the genes encoding these enzymes and others in the pathway, as well as alterations in the expression levels of the pathway constituents, can lead to antifungal drug resistance

Genes Involved

Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.

GeneSystematic NameEC NumberDescription
ERG1 YGR175C 1.14.14.17 Squalene epoxidase
ERG10 YPL028W 2.3.1.9 Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase)
ERG11 YHR007C 1.14.14.154 Lanosterol 14-alpha-demethylase
ERG12 YMR208W 2.7.1.36 Mevalonate kinase
ERG13 YML126C 2.3.3.10 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase
ERG2 YMR202W C-8 sterol isomerase
ERG20 YJL167W 2.5.1.1, 2.5.1.10 Farnesyl pyrophosphate synthetase
ERG24 YNL280C 1.3.1.70 C-14 sterol reductase
ERG25 YGR060W C-4 methyl sterol oxidase
ERG26 YGL001C 1.1.1.170 C-3 sterol dehydrogenase
ERG27 YLR100W 1.1.1.270 3-keto sterol reductase
ERG3 YLR056W 1.14.19.20 C-5 sterol desaturase
ERG4 YGL012W 1.3.1.71 C-24(28) sterol reductase
ERG5 YMR015C 1.14.19.41 C-22 sterol desaturase
ERG6 YML008C 2.1.1.41 Delta(24)-sterol C-methyltransferase
ERG7 YHR072W 5.4.99.7 Lanosterol synthase
ERG8 YMR220W 2.7.4.2 Phosphomevalonate kinase
ERG9 YHR190W 2.5.1.21 Farnesyl-diphosphate farnesyl transferase (squalene synthase)
HMG1 YML075C 1.1.1.34 HMG-CoA reductase
HMG2 YLR450W 1.1.1.34 HMG-CoA reductase
IDI1 YPL117C 5.3.3.2 Isopentenyl diphosphate:dimethylallyl diphosphate isomerase
MVD1 YNR043W 4.1.1.33 Mevalonate pyrophosphate decarboxylase

Functional Networks

Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.

Shared Annotations

Loading network…

GO-CAMs

GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.

Loading GO-CAMs…

GO Enrichment

Gene Ontology biological-process terms enriched among the genes in this pathway, computed with GO Term Finder. Terms are shown with the number of pathway genes annotated to them and the corrected p-value.

Loading GO enrichment…

References

List of references used specifically to curate the information on this page.

Resources

YeastPathways