Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.
Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.
| Gene | Systematic Name | EC Number | Description |
|---|---|---|---|
| ENO1 | YGR254W | 4.2.1.11 | Enolase I, a phosphopyruvate hydratase |
| ENO2 | YHR174W | 4.2.1.11 | Enolase II, a phosphopyruvate hydratase |
| FBA1 | YKL060C | 4.1.2.13 | Fructose 1,6-bisphosphate aldolase |
| FBP1 | YLR377C | 3.1.3.11 | Fructose-1,6-bisphosphatase |
| GPM1 | YKL152C | 5.4.2.11 | Tetrameric phosphoglycerate mutase |
| MAE1 | YKL029C | 1.1.1.38 | Mitochondrial malic enzyme |
| MDH2 | YOL126C | 1.1.1.37 | Cytoplasmic malate dehydrogenase |
| PCK1 | YKR097W | 4.1.1.49 | Phosphoenolpyruvate carboxykinase |
| PGI1 | YBR196C | 5.3.1.9 | Glycolytic enzyme phosphoglucose isomerase |
| PGK1 | YCR012W | 2.7.2.3 | 3-phosphoglycerate kinase |
| PYC1 | YGL062W | 6.4.1.1 | Pyruvate carboxylase isoform |
| PYC2 | YBR218C | 6.4.1.1 | Pyruvate carboxylase isoform |
| TDH1 | YJL052W | 1.2.1.12 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 |
| TDH2 | YJR009C | 1.2.1.12 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
| TDH3 | YGR192C | 1.2.1.12 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 |
Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.
GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.