Pathway: superpathway of histidine, purine, and pyrimidine biosynthesis

Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.

Pathway Name

superpathway of histidine, purine, and pyrimidine biosynthesis

Pathway ID

PRPP-PWY-1

SGD ID

SGD:S000249734

Genes

ADE1 | ADE12 | ADE13 | ADE16 | ADE17 | ADE2 | ADE4 | ADE6 | ADE8 | ADK1 | ADK2 | GUA1 | GUK1 | HIS1 | HIS2 | HIS3 | HIS4 | HIS5 | HIS6 | HIS7 | IMD2 | IMD3 | IMD4 | PRS1 | PRS2 | PRS3 | PRS4 | PRS5 | RNR1 | RNR2 | RNR3 | RNR4 | TRX1 | TRX2 | TRX3 | URA1 | URA10 | URA2 | URA3 | URA4 | URA5 | URA6 | URA7 | URA8 | YNK1

Chemical Compounds

(S)-dihydroorotate | 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide(4-) | 1-(5-phospho-beta-D-ribosyl)-ATP | 1-(5-phosphonato-beta-D-ribosyl)-5'-AMP(4-) | 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine | 2-oxoglutarate(2-) | 3-(imidazol-4-yl)-2-oxopropyl phosphate(2-) | 5'-xanthylate(2-) | 5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-) | 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide(4-) | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) | 5-amino-1-(5-phosphonato-D-ribosyl)imidazole-4-carboxylate | 5-amino-1-(5-phosphonato-beta-D-ribosyl)imidazol-3-ium | 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) | 5-phospho-beta-D-ribosylaminium(1-) | ADP(3-) | ATP(4-) | CTP(4-) | D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate(2-) | D-ribofuranose 5-phosphate(2-) | GDP(3-) | GTP(4-) | IMP(2-) | L-aspartate(1-) | L-glutamate(1-) | L-glutamine zwitterion | L-histidinal(1+) | L-histidine zwitterion | L-histidinol phosphate(1-) | L-histidinol(1+) | N(1)-(5-phospho-D-ribosyl)glycinamide(1-) | N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide(2-) | N(6)-(1,2-dicarboxylatoethyl)-AMP(4-) | N-carbamoyl-L-aspartate(2-) | NAD(1-) | NADH(2-) | SAICAR(4-) | UDP(3-) | UTP(4-) | adenosine 5'-monophosphate(2-) | ammonium | carbamate | carbamoyl phosphate(2-) | carbon dioxide | carboxyphosphate(2-) | dADP(3-) | dATP(4-) | dGDP(3-) | dGTP(4-) | diphosphoric acid | formate | fumarate(2-) | glycine zwitterion | guanosine 5'-monophosphate(2-) | hydrogencarbonate | hydrogenphosphate | hydron | orotate | orotidine 5'-phosphate(3-) | succinate(2-) | uridine 5'-monophosphate(2-) | water

Pathway Diagram

Diagram of the pathway from YeastPathways. Click "View interactive diagram at YeastPathways" for the zoomable, clickable version.

View interactive diagram at YeastPathways

Genes Involved

Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.

Functional Networks

Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.

Shared Annotations

GO-CAMs

GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.

GO Enrichment

Gene Ontology biological-process terms enriched among the genes in this pathway, computed with GO Term Finder. Terms are shown with the number of pathway genes annotated to them and the corrected p-value.