Pathway: diphthamide biosynthesis

Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.

Pathway Name

diphthamide biosynthesis

Pathway ID

PWY-6482-1

SGD ID

SGD:S000249769

Genes

DPH1 | DPH2 | DPH5 | KTI11 | RRT2

Chemical Compounds

2-(3-amino-3-carboxypropyl)-L-histidine dizwitterion | 2-[3-carboxylato-3-(methylammonio)propyl]-L-histidine dizwitterion | 5'-S-methyl-5'-thioadenosine | ATP(4-) | S-adenosyl-L-homocysteine zwitterion | S-adenosyl-L-methionine zwitterion | adenosine 5'-monophosphate(2-) | ammonium | diphosphoric acid | diphthamide residue | hydron

Pathway Diagram

Diagram of the pathway from YeastPathways. Click "View interactive diagram at YeastPathways" for the zoomable, clickable version.

View interactive diagram at YeastPathways

Genes Involved

Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.

Functional Networks

Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.

Shared Annotations

GO-CAMs

GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.

GO Enrichment

Gene Ontology biological-process terms enriched among the genes in this pathway, computed with GO Term Finder. Terms are shown with the number of pathway genes annotated to them and the corrected p-value.