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Pathway: sphingolipid biosynthesis (yeast)

Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.

Pathway Name
sphingolipid biosynthesis (yeast)
Pathway ID
SPHINGOLIPID-SYN-PWY-1
SGD ID
SGD:S000249644
Genes
AUR1 | CSG2 | DPL1 | IPT1 | LAC1 | LAG1 | LCB1 | LCB2 | LCB3 | LCB4 | LCB5 | LIP1 | SCS7 | SUR1 | SUR2 | TSC10 | YDC1 | YPC1 | YSR3
Chemical Compounds
1,2-diacyl-sn-glycerol | 1-phosphatidyl-1D-myo-inositol(1-) | 2-hydroxy fatty acid | 3-dehydrosphinganinium(1+) | ADP(3-) | ATP(4-) | GDP(3-) | GDP-alpha-D-mannose(2-) | L-serine zwitterion | N-acylphytosphingosine | NADP(3-) | NADPH(4-) | O-phosphonatoethanaminium(1-) | carbon dioxide | coenzyme A(4-) | dioxygen | hexadecanal | hydrogenphosphate | hydron | palmitoyl-CoA(4-) | phytosphingosine 1-phosphate(1-) | phytosphingosine(1+) | sphinganine 1-phosphate(1-) | sphinganine(1+) | water

Pathway Diagram

Diagram of the pathway from YeastPathways. Click "View interactive diagram at YeastPathways" for the zoomable, clickable version.

sphingolipid biosynthesis (yeast) pathway diagram

View interactive diagram at YeastPathways

Pathway Summary

Sphingolipids are essential components of the plasma membrane in all eukaryotic cells. S. cerevisiae cells make three complex sphingolipids: inositol-phosphoceramide (IPC), mannose-inositol-phosphoceramide (MIPC), and mannose-(inositol phosphate)2-ceramide (M(IP)2C) In the yeast plasma membrane sphingolipids concentrate with ergosterol to form lipid rafts, specialized membrane microdomains implicated in a variety of cellular processes, including sorting of membrane proteins and lipids, as well as organizing and regulating signaling cascades Intermediates in sphingolipid biosynthesis have been shown to play important roles as signaling molecules and growth regulators. Sphingolipid long chain bases (LCBs), dihydrosphingosine (DHS) and phytosphingosine (PHS), have been implicated as secondary messengers in signaling pathways that regulate heat stress response Other intermediates, phytoceramide and long-chain base phosphates (LCBPs), have been shown to be components of the tightly-controlled ceramideLCBP rheostat, which regulates cell growth Since phosphoinositol-containing sphingolipids are unique to fungi, the sphingolipid biosynthesis pathway is considered a target for antifungal drugs

Genes Involved

Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.

GeneSystematic NameEC NumberDescription
AUR1 YKL004W 2.7.1.227 Phosphatidylinositol:ceramide phosphoinositol transferase
CSG2 YBR036C Calcium release channel involved in ER calcium homeostasis
DPL1 YDR294C 4.1.2.27 Dihydrosphingosine phosphate lyase
IPT1 YDR072C 2.7.1.228 Inositolphosphotransferase
LAC1 YKL008C 2.3.1.297 Ceramide synthase component
LAG1 YHL003C 2.3.1.297 Ceramide synthase component
LCB1 YMR296C 2.3.1.50 Component of serine palmitoyltransferase
LCB2 YDR062W 2.3.1.50 Serine palmitoyltransferase component
LCB3 YJL134W Long-chain base-1-phosphate phosphatase
LCB4 YOR171C 2.7.1.91 Sphingoid long-chain base kinase
LCB5 YLR260W 2.7.1.91 Minor sphingoid long-chain base kinase
LIP1 YMR298W Ceramide synthase subunit
SCS7 YMR272C 1.14.18.6, 1.14.18.7 Sphingolipid alpha-hydroxylase
SUR1 YPL057C 2.4.1.370 Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit
SUR2 YDR297W Sphinganine C4-hydroxylase
TSC10 YBR265W 1.1.1.102 3-ketosphinganine reductase
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism
YPC1 YBR183W Alkaline ceramidase
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase

Functional Networks

Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.

Shared Annotations

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GO-CAMs

GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.

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GO Enrichment

Gene Ontology biological-process terms enriched among the genes in this pathway, computed with GO Term Finder. Terms are shown with the number of pathway genes annotated to them and the corrected p-value.

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References

List of references used specifically to curate the information on this page.

Resources

YeastPathways