Pathway: TCA cycle, aerobic respiration
Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.
- Pathway Name
- TCA cycle, aerobic respiration
- Pathway ID
- TCA-EUK-PWY
- SGD ID
- SGD:S000249725
- Genes
- ACO1 | ACO2 | CIT1 | CIT3 | FUM1 | IDH1 | IDH2 | KGD1 | KGD2 | LPD1 | LSC1 | LSC2 | MAE1 | MDH1 | PYC1 | PYC2 | SDH1 | SDH2 | SDH3 | SDH4 | SDH9
- Aliases
- TCA ; TCA cycle ; tricarboxylic acid cycle ; citric acid cycle
- Chemical Compounds
- (S)-malate(2-) | 2-oxoglutarate(2-) | ADP(3-) | ATP(4-) | D-threo-isocitrate(3-) | NAD(1-) | NADH(2-) | acetyl-CoA(4-) | carbon dioxide | cis-aconitate(3-) | citrate(3-) | coenzyme A(4-) | electron | fumarate(2-) | hydrogencarbonate | hydrogenphosphate | hydron | oxaloacetate(2-) | pyruvate | succinate(2-) | succinyl-CoA(5-) | ubiquinol | ubiquinones | water
Pathway Summary
Genes Involved
Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.
| Gene | Systematic Name | EC Number | Description |
|---|---|---|---|
| ACO1 | YLR304C | 4.2.1.3 | Aconitase |
| ACO2 | YJL200C | Putative mitochondrial aconitase isozyme | |
| CIT1 | YNR001C | 2.3.3.1 | Mitochondrial citrate synthase |
| CIT3 | YPR001W | 2.3.3.1 | Dual specificity mitochondrial citrate and methylcitrate synthase |
| FUM1 | YPL262W | 4.2.1.2 | Fumarase |
| IDH1 | YNL037C | 1.1.1.41 | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
| IDH2 | YOR136W | 1.1.1.41 | Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
| KGD1 | YIL125W | 1.2.4.2 | Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex |
| KGD2 | YDR148C | 2.3.1.61 | Dihydrolipoyl transsuccinylase |
| LPD1 | YFL018C | 1.8.1.4 | Dihydrolipoamide dehydrogenase |
| LSC1 | YOR142W | 6.2.1.5 | Alpha subunit of succinyl-CoA ligase |
| LSC2 | YGR244C | 6.2.1.5 | Beta subunit of succinyl-CoA ligase |
| MAE1 | YKL029C | 1.1.1.38 | Mitochondrial malic enzyme |
| MDH1 | YKL085W | 1.1.1.37 | Mitochondrial malate dehydrogenase |
| PYC1 | YGL062W | 6.4.1.1 | Pyruvate carboxylase isoform |
| PYC2 | YBR218C | 6.4.1.1 | Pyruvate carboxylase isoform |
| SDH1 | YKL148C | 1.3.5.1 | Flavoprotein subunit of succinate dehydrogenase |
| SDH2 | YLL041C | 1.3.5.1 | Iron-sulfur protein subunit of succinate dehydrogenase |
| SDH3 | YKL141W | Subunit of succinate dehydrogenase and of TIM22 translocase | |
| SDH4 | YDR178W | Membrane anchor subunit of succinate dehydrogenase (SDH) | |
| SDH9 | YJL045W | 1.3.5.1 | Minor succinate dehydrogenase isozyme |
Functional Networks
Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.
Shared Annotations
GO-CAMs
GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.
Resources
YeastPathways