AboutBlogDownloadExploreHelpGet Data

Pathway: salvage pathways of pyrimidine deoxyribonucleotides

Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.

Pathway Name
salvage pathways of pyrimidine deoxyribonucleotides
Pathway ID
YEAST-SALV-PYRMID-DNTP
SGD ID
SGD:S000249773
Genes
CDD1 | URH1 | URK1
Aliases
dpyr ; deoxypyrimidine nucleotide/nucleoside metabolism
Chemical Compounds
2'-deoxycytidine | 2'-deoxycytosine 5'-monophosphate(2-) | 2'-deoxyuridine | 2-deoxy-alpha-D-ribose 1-phosphate(2-) | 2-deoxypentose | ADP(3-) | ATP(4-) | ammonium | cytosine | dTMP(2-) | dUMP(2-) | hydrogenphosphate | hydron | thymidine | thymine | uracil | water

Pathway Diagram

Diagram of the pathway from YeastPathways. Click "View interactive diagram at YeastPathways" for the zoomable, clickable version.

salvage pathways of pyrimidine deoxyribonucleotides pathway diagram

View interactive diagram at YeastPathways

Pathway Summary

The deoxynucleotides required for DNA synthesis can either be made de novo, or they can be salvaged from endogenous degradation processes . If the required substrates are available, the salvage pathways of pyrimidine deoxyribonucleotides are preferred over de novo synthesis pathways for pyrimidine biosynthesis . As with many of the metabolic pathways of S. cerevisiae, the pathways for the salvage of pyrimidine deoxyribonucleotides are regulated by a variety of processes, including transcription regulation . Saccharomyces cerevisiae contains three enzymes (Urk1p, Urh1p, and Cdd1p) that are able to salvage deoxycytidine in vitro . However of these three enzymes, only Urk1p and Urh1p have been shown to metabolize deoxycytidine in vivo . In vitro Cdd1p has been shown to deaminate deoxycytidine to form deoxyuridine, however the biological significance of this is doubtful . Evidence that Cdd1p is not important for deoxypyrimidine salvage comes from the observation that fyc1 urh1 urk1 triple mutants are resistant to 5-fluorodeoxycytidine, indicating that these cells are not able to metabolize deoxycytidine . Also deoxyuridine does not allow growth of ura- strains, indicating that deoxyuridine cannot be utilized as a sole source of pyrimidines in S. cerevisiae .

Genes Involved

Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.

GeneSystematic NameEC NumberDescription
CDD1 YLR245C 3.5.4.5 Cytidine deaminase
URH1 YDR400W 3.2.2.3 Uridine nucleosidase (uridine-cytidine N-ribohydrolase)
URK1 YNR012W 2.7.1.48 Uridine/cytidine kinase

Functional Networks

Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.

Shared Annotations

Loading network…

GO-CAMs

GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.

Loading GO-CAMs…

GO Enrichment

Gene Ontology biological-process terms enriched among the genes in this pathway, computed with GO Term Finder. Terms are shown with the number of pathway genes annotated to them and the corrected p-value.

Loading GO enrichment…

References

List of references used specifically to curate the information on this page.

Resources

YeastPathways