UFD2 / YDL190C Homology
- Standard Name
- UFD2 1
- Systematic Name
- YDL190C
- SGD ID
- SGD:S000002349
- Feature Type
- ORF , Verified
- Description
- E4 ubiquitin ligase that extends E3-dependent Ub chains; catalyzes K48-linked multi-monoubiquitination of Ufd4p-assembled, K29-linked Ub chains prior to substrate degradation; binds and converts C-terminally extended Ub (Ubi4p) into an unanchored chain to mark client proteins for stress-induced degradation; role in Ub-fusion degradation, the OLE pathway, and the ERAD pathway; U-box family member; human homologs, UBE4A and UBE4B, implicated in neurological disease and tumor development 1 2 3 4 5 6 7 8 9 10 11
- Name Description
- Ubiquitin Fusion Degradation 1
- Comparative Info
-
Homologs
Homology calls are sourced from the Alliance of Genome Resources. Many aspects of data integration presented at the Alliance require a common set of orthology relationships among genes for the organisms represented, including human. The Alliance provides the results of all methods that have been benchmarked by the Quest for Orthologs Consortium (QfO). The homolog inferences from the different methods have been integrated using the DRSC Integrative Ortholog Prediction Tool (DIOPT), which integrates a number of existing methods including those used by the Alliance: Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, and ZFIN.
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| HOMOLOG ID | Species | Gene ID | Gene name | Source |
|---|
Functional Complementation
Information about cross-species functional complementation between yeast and other species, curated by SGD and the Princeton Protein Orthology Database (P-POD).
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
|---|
Fungal Homologs
Fungal Homology calls are sourced from AllianceMine, which compiles fungal homology calls from FungiDB, CGD, Panther, PomBase, TreeFam, HomoloGene, and SGD.
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| HOMOLOG ID | Species | Gene ID | Gene name | Description | Source |
|---|
External Identifiers
List of external identifiers for the protein from various database sources.
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| Alias ID | External ID | Source |
|---|
Resources
Homologs
AnalogYeast | BLASTP at NCBI | CGD | FungiDB | PhylomeDB | PomBase | YGOB | YOGY | CGD Synteny Browser
Protein Databases
AlphaFold Protein Structure | GPMDB | ModelArchive | Pfam domains | SUPERFAMILY | TopologYeast | UniProtKB
Localization
CYCLoPs | LibrarYeast | LoQAtE | YeastGFP | YeastRC Public Images | YeastRGB | YPL+
Post-translational Modifications
CoSMoS.c. | PhosphoGRID | PhosphoPep
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi