PHO23 / YNL097C Phenotype

Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided.

Summary

PHO23/YNL097C is a non-essential gene in reference strain S288C; null mutants are viable but grow slowly and display haploinsufficiency, decreased utilization of carbon and nitrogen sources, decreased respiratory growth rate, decreased filamentous growth, and absent invasive growth. Null mutants exhibit abnormal chemical compound accumulation, increased chemical compound excretion, abnormal protein/peptide distribution, increased protein/peptide modification, abnormal and increased RNA accumulation, abnormal vacuolar morphology, decreased vacuolar transport, and decreased endocytosis. Stress resistance phenotypes are context-dependent: null mutants show decreased innate thermotolerance, increased heat sensitivity, decreased desiccation resistance, decreased starvation resistance, decreased overall stress resistance, decreased resistance to toxins, and variable resistance to chemicals (both increased and decreased depending on the compound), while metal resistance and oxidative stress resistance are increased. Null mutants display increased silencing, decreased mutation frequency, decreased transposable element transposition, decreased replicative lifespan, increased sporulation efficiency, and decreased competitive fitness. Overexpression of PHO23 results in decreased or normal vegetative growth rate (context-dependent) and increased invasive growth. Reduction-of-function alleles exhibit increased acid pH resistance, increased osmotic stress resistance, and variable resistance to metals and chemicals (both increased and decreased depending on the specific stressor).

Annotations

A phenotype is defined as an observable (e.g., apoptosis) and a qualifier (e.g., increased). There may be more than one row with the same phenotype if that phenotype was observed in separate studies or in different conditions, strains, alleles, etc.

Shared Phenotypes

This diagram displays phenotype observables (purple squares) that are shared between the given gene (yellow circle) and other genes (gray circles) based on the number of phenotype observables shared (adjustable using the slider at the bottom).

Resources