Biochemical pathways in S. cerevisiae are manually curated and maintained in the YeastPathways database. This page summarizes the genes, enzymes, and metabolites involved in the pathway, along with the curated literature.
Genes whose products participate in this pathway, with their systematic names, EC numbers (where the gene product is an enzyme with an assigned EC number), and the gene's SGD description.
| Gene | Systematic Name | EC Number | Description |
|---|---|---|---|
| CYS3 | YAL012W | 4.4.1.1 | Cystathionine gamma-lyase |
| CYS4 | YGR155W | 4.2.1.22 | Cystathionine beta-synthase |
| HOM2 | YDR158W | 1.2.1.11 | Aspartic beta semi-aldehyde dehydrogenase |
| HOM3 | YER052C | 2.7.2.4 | Aspartate kinase (L-aspartate 4-P-transferase) |
| HOM6 | YJR139C | 1.1.1.3 | Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) |
| MET10 | YFR030W | 1.8.1.2 | Subunit alpha of assimilatory sulfite reductase |
| MET14 | YKL001C | 2.7.1.25 | Adenylylsulfate kinase |
| MET16 | YPR167C | 1.8.4.8 | 3'-phosphoadenylsulfate reductase |
| MET17 | YLR303W | 2.5.1.47, 2.5.1.49 | O-acetyl homoserine-O-acetyl serine sulfhydrylase |
| MET2 | YNL277W | 2.3.1.31 | L-homoserine-O-acetyltransferase |
| MET3 | YJR010W | 2.7.7.4 | ATP sulfurylase |
| MET5 | YJR137C | 1.8.1.2 | Sulfite reductase beta subunit |
| MET6 | YER091C | 2.1.1.14 | Cobalamin-independent methionine synthase |
| MET7 | YOR241W | 6.3.2.17 | Folylpolyglutamate synthetase |
| SAM1 | YLR180W | 2.5.1.6 | S-adenosylmethionine synthetase |
| SAM2 | YDR502C | 2.5.1.6 | S-adenosylmethionine synthetase |
| STR2 | YJR130C | 2.5.1.48 | Cystathionine gamma-synthase, converts cysteine into cystathionine |
| STR3 | YGL184C | 4.4.1.13 | Peroxisomal cystathionine beta-lyase |
| TRX1 | YLR043C | Cytoplasmic thioredoxin isoenzyme | |
| TRX2 | YGR209C | Cytoplasmic thioredoxin isoenzyme | |
| TRX3 | YCR083W | Mitochondrial thioredoxin |
Functional Networks show how the genes in this pathway work together: a graph linking the pathway to its genes and their shared GO biological-process terms and phenotype observables, and the GO-CAM causal activity models that involve these genes.
GO-CAM (Gene Ontology Causal Activity Model) pathway models that involve the genes in this pathway. A gene can participate in more than one model, so use the dropdown to switch between them; the model for this pathway is shown by default.