FIG2 / YCR089W Overview
- Standard Name
- FIG2 1
- Systematic Name
- YCR089W
- SGD ID
- SGD:S000000685
- Feature Type
- ORF , Verified
- Description
- Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication 1 2 3
- Name Description
- Factor-Induced Gene 1
- Paralog
- AGA1 3
- Comparative Info
-
Sequence
The S. cerevisiae Reference Genome sequence is derived from laboratory strain S288C. Download DNA or protein sequence, view genomic context and coordinates. Click "Sequence Details" to view all sequence information for this locus, including that for other strains.
- Summary
- FIG2/YCR089W is located on the right arm of chromosome III between actin-binding protein ABP1 and uncharacterized protein YCR090C; coding sequence is 4830 nucleotides long; gene structure includes insertions and several deletions in different alternative reference strains, with 30 synonymous, 28 nonsynonymous, and 4 untranslatable SNPs; FIG2 has a paralog, AGA1, that arose from the whole genome duplication
Analyze Sequence
S288C only
BLASTN | BLASTP | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species
BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | CGD Synteny Browser
S288C vs. other strains
Protein
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein.
- Summary
- Fig2p is 1609 amino acids long; phosphorylated on T269
Alleles
Curated mutant alleles for the specified gene, listed alphabetically. Click on the allele name to open the allele page. Click "SGD search" to view all alleles in search results.
View all FIG2 alleles in SGD search
Gene Ontology
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a reference, and an evidence code. SGD has manually curated and high-throughput GO Annotations, both derived from the literature, as well as computational, or predicted, annotations. Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes.
- Summary
- Protein involved in filamentous growth, invasive growth, mating and cellular fusion; localizes to cell wall and shmoo
View computational annotations
Biological Process
- Manually Curated
- involved in cytogamy (IMP)
- involved in filamentous growth of a population of unicellular organisms (IMP)
- involved in invasive growth in response to glucose limitation (IMP)
- involved in negative regulation of protein localization to cell tip (IMP)
- involved in response to pheromone triggering conjugation with cellular fusion (IMP)
Cellular Component
- Manually Curated
- is active in cell-cell contact zone (IMP)
- located in mating projection (IDA)
- High-Throughput
- located in cell periphery (HDA)
Phenotype
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. In addition, annotations are classified as classical genetics or high-throughput (e.g., large scale survey, systematic mutation set). Whenever possible, allele information and additional details are provided. Click "Phenotype Details" to view all phenotype annotations and evidence for this locus as well as phenotypes it shares with other genes.
- Summary
- Non-essential gene in reference strain S288C; null mutant causes chromosome instability and defective mating with abnormal cell fusion, mating projection morphology, and nuclear fusion; exhibits cell wall stress with increased Slt2p phosphorylation and abnormal spindle organization that is partially suppressed by osmotic support; shows context-dependent mating efficiency defects and decreased viability during mating; decreased resistance to multiple compounds and decreased competitive fitness in minimal medium; overexpression promotes filamentous growth and adhesion in Sigma1278b; the null mutant of paralog AGA1 is viable; the fig2 aga1 double mutant is viable but sterile; the fig2 aga1 aga2 triple mutant and the fig2 aga1 sag1 triple mutant are also viable but sterile
Classical Genetics
- null
- overexpression
Interaction
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction type, name of the interactor, assay type (e.g., Two-Hybrid), annotation type (e.g., manual or high-throughput), and a reference, as well as other experimental details. Click "Interaction Details" to view all interaction annotations and evidence for this locus, including an interaction visualization.
- Summary
- Fig2p interacts physically with proteins involved in RNA catabolism; FIG2 interacts genetically with genes involved in transcription by RNA polymerase II
103 total interactions for 87 unique genes
Regulation
The number of putative Regulators (genes that regulate it) and Targets (genes it regulates) for the given locus, based on experimental evidence. This evidence includes data generated through high-throughput techniques. Click "Regulation Details" to view all regulation annotations, shared GO enrichment among regulation Targets, and a regulator/target diagram for the locus.
Expression
Expression data are derived from records contained in the Gene Expression Omnibus (GEO), and are first log2 transformed and normalized. Referenced datasets may contain one or more condition(s), and as a result there may be a greater number of conditions than datasets represented in a single clickable histogram bar. The histogram division at 0.0 separates the down-regulated (green) conditions and datasets from those that are up-regulated (red). Click "Expression Details" to view all expression annotations and details for this locus, including a visualization of genes that share a similar expression pattern.
All Curated Literature
All manually curated literature for the specified gene, shown as a count of references by year of publication followed by the most recent papers. Click "Literature Details" or "See all" to view all literature information for this locus, organized into topics according to their relevance to the gene (Primary Literature, Additional Literature, or Review).
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